Journal of Anaesthesiology Clinical Pharmacology

ORIGINAL ARTICLE
Year
: 2020  |  Volume : 36  |  Issue : 4  |  Page : 524--530

Effect of caudal bupivacaine alone and with adjuvant fentanyl and nalbuphine to minimize the catheter-related bladder discomfort after tubeless percutaneous nephrolithotomy: A prospective randomized study


Dinesh J Prajapati, Manoj Patel, Pankaj Patel, Mohankumar Vijayakumar, Arvind Ganpule, Deepak Mistry 
 Department of Anaesthesiology, Muljibhai Patel Urological Hospital, Nadiad, Gujarat, India

Correspondence Address:
Dr. Dinesh J Prajapati
Department of Anaesthesiology, Muljibhai Patel Urological Hospital, Nr Dr. Virendra Desai Road, Nadiad - 387 001, Gujarat
India

Background and Aims: Catheter-related bladder discomfort (CRBD) is a major cause of postoperative morbidity following urological procedures. The aim of this study was to compare the effect of caudal bupivacaine alone and with adjuvant fentanyl and nalbuphine to minimize the severity of CRBD after tubeless percutaneous nephrolithotomy (PCNL). Material and Methods: A randomized prospective study was conducted on one hundred thirty-two (American society of Anaesthesiologist physical status I to II) patients who presented for tubeless PCNL under general anesthesia. Patients were randomly divided into four groups control (C), bupivacaine (B), bupivacaine-fentanyl (BF), and bupivacaine-nalbuphine (BN) by using computer-generated codes. All patients received local infiltration at the procedure site while Groups B, BF, and BN received caudal epidural block (CEB) under ultrasound guidance after conclusion of the procedure. Groups B, BF, and BN received bupivacaine alone, bupivacaine-fentanyl, and bupivacaine-nalbuphine, respectively, for CEB. Patients were monitored 24 h for CRBD scale, visual analogue score (VAS), and duration of analgesia at 30 min, 1, 2, 4, 6, 12, 18, and 24 h intervals. The analgesics were supplemented if the CRBD score was >2 and VAS was ≥4. Student t-test, analysis of variance, and Chi-square test were applied for quantitative, within group occurrence, and qualitative analysis respectively. Results: The CRBD scores were considerably lower in the Groups BF and BN as compared to Groups C and B during the first four hours. The duration of analgesia was significantly prolonged in Group BN (475 ± 47 min) versus BF (320 ± 68 min) versus B (104 ± 40 min) versus C (26 ± 14 min). Conclusions: The severity of CRBD can be reduced with CEB. The effect of CEB can be prolonged with the addition of opioid.


How to cite this article:
Prajapati DJ, Patel M, Patel P, Vijayakumar M, Ganpule A, Mistry D. Effect of caudal bupivacaine alone and with adjuvant fentanyl and nalbuphine to minimize the catheter-related bladder discomfort after tubeless percutaneous nephrolithotomy: A prospective randomized study.J Anaesthesiol Clin Pharmacol 2020;36:524-530


How to cite this URL:
Prajapati DJ, Patel M, Patel P, Vijayakumar M, Ganpule A, Mistry D. Effect of caudal bupivacaine alone and with adjuvant fentanyl and nalbuphine to minimize the catheter-related bladder discomfort after tubeless percutaneous nephrolithotomy: A prospective randomized study. J Anaesthesiol Clin Pharmacol [serial online] 2020 [cited 2021 Apr 18 ];36:524-530
Available from: https://www.joacp.org/article.asp?issn=0970-9185;year=2020;volume=36;issue=4;spage=524;epage=530;aulast=Prajapati;type=0