Journal of Anaesthesiology Clinical Pharmacology

: 2020  |  Volume : 36  |  Issue : 3  |  Page : 297--302

Anesthesia and Alzheimer's: A review

Jeffrey Y Sun 
 NYU Langone Health, Department of Anesthesiology, Perioperative Care and Pain Medicine, New York, New York, USA

Correspondence Address:
Dr. Jeffrey Y Sun
NYU Langone Health, Department of Anesthesiology, New York, New York - 10016

As early as 1955, it was Bedford who provided description of cognitive changes in elderly patients following anesthesia and surgery. Reports of individuals with catastrophic, non-stroke-related decline in cognitive functions following anesthesia and surgery lead to a perception in the lay population that anesthesia and surgery have the potential to greatly exaggerate the progression of dementia, particularly Alzheimer's disease (AD). There is a concern that anesthesia and surgery could cause irreversible impairment, leading to AD. This could also explain the accelerated decline in patients with mild cognitive impairment. We seek to explore the relevant literature to determine whether a correlation exists and then propose a possible pathophysiologic mechanism.

How to cite this article:
Sun JY. Anesthesia and Alzheimer's: A review.J Anaesthesiol Clin Pharmacol 2020;36:297-302

How to cite this URL:
Sun JY. Anesthesia and Alzheimer's: A review. J Anaesthesiol Clin Pharmacol [serial online] 2020 [cited 2021 Jan 19 ];36:297-302
Available from:;year=2020;volume=36;issue=3;spage=297;epage=302;aulast=Sun;type=0