Journal of Anaesthesiology Clinical Pharmacology

ORIGINAL ARTICLE
Year
: 2014  |  Volume : 30  |  Issue : 4  |  Page : 520--525

Effect of intramucosal infiltration of different concentrations of adrenaline on hemodynamics during transsphenoidal surgery


Nidhi Bhatia1, Babita Ghai1, Kishore Mangal1, Jyotsna Wig1, Kanchan K Mukherjee2 
1 Departments of Anaesthesia and Intensive Care, PGIMER, Chandigarh, India
2 Department of Neurosurgery, PGIMER, Chandigarh, India

Correspondence Address:
Nidhi Bhatia
Department of Anaesthesia and Intensive Care, PGIMER, Chandigarh
India

Background and Aims: Neurosurgeons routinely instill vasopressors, with or without local anesthetics, to prepare nasal passages prior to transsphenoidal surgeries. As there is a paucity of data comparing the effect of intramucosal nasal infiltration of different concentrations of adrenaline that is, 1:200,000 and 1:400,000 in patients undergoing transsphenoidal surgery, we conducted this study to evaluate the effect of these two concentrations of adrenaline with 2% lignocaine on hemodynamics as well as bleeding. Materials and Methods: Fifty-two American Society of Anesthesiologists I/II patients, aged 15-70 years, undergoing transsphenoidal surgery for pituitary or sellar masses were enrolled. Prior to surgical incision, nasal septal mucosa was infiltrated with lignocaine-adrenaline solution, after randomly allocating them to one of the two groups, with patients in Group A receiving intramucosal infiltration using 2% lignocaine with 1:200,000 adrenaline and those in Group B receiving 2% lignocaine with 1:400,000 adrenaline. Following infiltration, hemodynamic parameters were recorded every 1 min for 5 min and thereafter at every 5 min interval. Results: Fewer patients (3/24 [12.5%]) in Group B had a rise of >50% in systolic blood pressure, from baseline values, after nasal mucosa infiltration as compared with patients in Group A (9/24 [37.5%]). In addition, mean rise in systolic, diastolic and mean arterial pressure was also significantly lower in Group B as compared with Group A. Conclusion: Adrenaline in a concentration of 1:400,000 added to 2% lignocaine for nasal mucosa infiltration produces less hemodynamic response as compared with adrenaline 1:200,000 added to 2% lignocaine while at the same time providing similar operating conditions.


How to cite this article:
Bhatia N, Ghai B, Mangal K, Wig J, Mukherjee KK. Effect of intramucosal infiltration of different concentrations of adrenaline on hemodynamics during transsphenoidal surgery .J Anaesthesiol Clin Pharmacol 2014;30:520-525


How to cite this URL:
Bhatia N, Ghai B, Mangal K, Wig J, Mukherjee KK. Effect of intramucosal infiltration of different concentrations of adrenaline on hemodynamics during transsphenoidal surgery . J Anaesthesiol Clin Pharmacol [serial online] 2014 [cited 2021 Feb 26 ];30:520-525
Available from: https://www.joacp.org/article.asp?issn=0970-9185;year=2014;volume=30;issue=4;spage=520;epage=525;aulast=Bhatia;type=0