Users Online: 471 Home Print this page Email this page Small font sizeDefault font sizeIncrease font size  
Home | About us | Editorial board | Search | Ahead of print | Current issue | Archives | Submit article | Instructions | Subscribe | Contacts | Login 


RSACP wishes to inform that it shall be discontinuing the dispatch of print copy of JOACP to it's Life members. The print copy of JOACP will be posted only to those life members who send us a written confirmation for continuation of print copy.
Kindly email your affirmation for print copies to [email protected] preferably by 30th June 2019.

 

 
Table of Contents
LETTERS TO EDITOR
Year : 2020  |  Volume : 36  |  Issue : 4  |  Page : 570-571

Silent” hypoxemia in COVID-19: Hunt for the shunt!


1 Department of Cardiac Anaesthesia, Atal Bihari Vajpayee Institute of Medical Sciences (ABVIMS) and Dr. Ram Manohar Lohia Hospital, Baba Kharak Singh Marg, New Delhi, India
2 Department of Cardiac Anaesthesia, Cardiothoracic Centre, CNC, All India Institute of Medical Sciences, New Delhi Ansari Nagar, New Delhi, India

Date of Submission09-Aug-2020
Date of Acceptance21-Sep-2020
Date of Web Publication18-Jan-2021

Correspondence Address:
Dr. Neeti Makhija
Department of Cardiac Anaesthesia, Room No. 9, 7th Floor, Cardiothoracic Centre, All India Institute of Medical Sciences, Ansari Nagar, New Delhi - 110 029
India
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/joacp.JOACP_491_20

Rights and Permissions

How to cite this article:
ItiShri, Magoon R, Makhija N, Kashav R. “Silent” hypoxemia in COVID-19: Hunt for the shunt!. J Anaesthesiol Clin Pharmacol 2020;36:570-1

How to cite this URL:
ItiShri, Magoon R, Makhija N, Kashav R. “Silent” hypoxemia in COVID-19: Hunt for the shunt!. J Anaesthesiol Clin Pharmacol [serial online] 2020 [cited 2021 May 7];36:570-1. Available from: https://www.joacp.org/text.asp?2020/36/4/570/307207



Dear Editor,

We read with interest the exemplary description of the respiratory and cardiovascular effects of COVID-19 infection by Kapoor, featured recently in the journal.[1] While we appreciate the elaboration upon the multi-faceted spectrum of the novel SARS-Cov-2 pneumonia in the index article, the lack of dyspnea (”silent”or “happy” hypoxemia) and plummeting desaturation in this cohort of patients, continue to bewilder and baffle the fraternity at large.

In this context, we wish to impress upon the very interesting hypothesis recently put forth by Fisher, regarding the role of the unanticipated opening of an underlying patent foramen ovale (PFO) in explaining this mysterious hypoxemia.[2] Nevertheless, a number of factors surrounding this hypothesis merit attention:

  1. Considering the existing literature on the magnitude of intra-thoracic shunt in acute respiratory distress syndrome (ARDS)[2] and given the astonishingly high frequency of a probe-patent PFO (20-25%)[3]; the intra-cardiac right-to-left (R-L) shunt could add significantly to the intrapulmonary shunt in aggravating the systemic hypoxemia ahead of the deterioration in the respiratory mechanics.
  2. In addition, Gattinoni and colleagues have also adequately highlighted the importance of estimating the shunt fraction in the COVID-related ARDS (as they describe it as a not so “typical” ARDS).[4]
  3. Moreover, the accompanying pathological elevation of right atrial pressures (RAP) (in background of pulmonary artery hypertension owing to the ongoing inflammatory process) is expected to promote the intra-cardiac R-L shunting (precluded in health by the physiologically higher left atrial pressures compared to RAP) which is unlikely to respond well to oxygenation wherein positive pressure ventilation will only make the matter worse.[1],[5]


While the debate on the mechanisms of “silent” hypoxemia continues to snowball with every passing day of the pandemic, acknowledgement to the shunt patho-physiology and bedside echocardiographic exploration for PFO cannot only provide anatomico-physiological clues to the deteriorating oxygen saturation rather the degree of R-L shunt can also guide the monitoring of the concomitant pulmonary vasodilator therapy with the potential of benefitting a considerable number of critically ill COVID-19 patients.

Financial support and sponsorship

Nil.

Conflicts of interest

There are no conflicts of interest.



 
  References Top

1.
Kapoor MC. Respiratory and cardiovascular effects of COVID-19 infection and their management. J Anaesthesiol Clin Pharmacol.doi: 10.4103/joacp.JOACP_242_20  Back to cited text no. 1
    
2.
Fisher HK. Hypoxemia in COVID-19 patients: An hypothesis. Med Hypotheses 2020;143:110022.doi: 10.1016/j.mehy. 2020.110022  Back to cited text no. 2
    
3.
Wu LA, Malouf JF, Dearani JA, Hagler DJ, Reeder GS, Petty GW, et al. Patent foramen ovale in cryptogenic stroke: Current understanding and management options. Arch Intern Med 2004;164:950-6.  Back to cited text no. 3
    
4.
Gattinoni L, Coppola S, Cressoni M, Busana M, Rossi S, Chiumello D. COVID-19 does not lead to a “Typical” acute respiratory distress syndrome. Am J Respir Crit Care Med 2020;201:1299-300.  Back to cited text no. 4
    
5.
Magoon R. COVID-19 and congenital heart disease: Cardiopulmonary interactions for the worse! Paediatr Anaesth 2020;30;1160-1  Back to cited text no. 5
    




 

Top
 
  Search
 
    Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
    Access Statistics
    Email Alert *
    Add to My List *
* Registration required (free)  

 
  In this article
   References

 Article Access Statistics
    Viewed396    
    Printed2    
    Emailed0    
    PDF Downloaded81    
    Comments [Add]    

Recommend this journal