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FORUM
Year : 2020  |  Volume : 36  |  Issue : 4  |  Page : 552-555

Genetics of malignant hyperthermia: A brief update


1 Department of Anesthesiology, University of Minnesota, Minneapolis, MN, USA
2 University of Minnesota Medical School, Minneapolis, MN, USA
3 Department of Lab Medicine and Pathology, University of Minnesota, Minneapolis, MN, USA

Correspondence Address:
Dr. Kumar G Belani
Department of Anesthesiology, University of Minnesota, Minneapolis, MN
USA
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/joacp.JOACP_360_19

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Malignant hyperthermia susceptibility (MHS) and the associated condition malignant hyperthermia (MH) are rare but well-known disorders in the field of anesthesiology. MHS is usually determined by a history of a family member developing a positive episode during general anesthesia and then confirmed by an invasive caffeine halothane contracture test (CHCT). More recently, within the context of MH as a pharmacogenetic disorder, the question of whether or not MHS can be principally genetically determined is of high importance as knowledge of detailed pathogenesis may prevent against its largely invariable lethality if untreated. Thus, in this brief report, genetic terms, as well as updates in the genetics of MHS, will be reviewed in order to better understand both the condition and the current research.


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