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| LETTER TO EDITOR |
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| Year : 2017 | Volume
: 33
| Issue : 3 | Page : 411-412 |
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Effect of dexmedetomidine on blood glucose during surgery
Priyanka Sethi1, Neeraj Gupta2
1 Department of Anaesthesia and Critical Care, All Institute of Medical Sciences, Jodhpur, Rajasthan, India
2 Department of Paediatrics, All Institute of Medical Sciences, Jodhpur, Rajasthan, India
| Date of Web Publication | 11-Sep-2017 |
Correspondence Address:
Priyanka Sethi
301/1, AIIMS Residential Complex, Basni Phase-II, AIIMS, Jodhpur- 342 005, Rajasthan
India
 Source of Support: None, Conflict of Interest: None  | Check |
DOI: 10.4103/0970-9185.173320
How to cite this article:
Sethi P, Gupta N. Effect of dexmedetomidine on blood glucose during surgery. J Anaesthesiol Clin Pharmacol 2017;33:411-2 |
Sir,
We read the article by Harsoor et al. with great interest.[1] However, we would like to point out few issues.
First, the authors have not mentioned any actual baseline value of blood glucose level for calculating sample size. They have assumed a 20% change in the blood glucose levels in the intervention arm (dexmedetomidine group) from the baseline. Similarly, authors have assumed equal standard deviation of blood glucose level in both the groups without mentioning an actual figure. It is not clear that how the sample size was calculated without these actual figures.[2]
Second, there is no comment on “allocation concealment.” Authors have rightly pointed toward a method of “random sequence generation” and “blinding” but there is no mention about the concealment of allocation. Allocation concealment is an important second element of any randomized controlled trial and takes care of “selection bias” and without which randomization collapses in a trial.[3]
Despite these limitations, we appreciate the authors for their work, which opens up new arenas of research on dexmedetomidine in blunting the stress response during surgery.
Financial support and sponsorship
Nil.
Conflicts of interest
There are no conflicts of interest.
| References | |  |
| 1. | Harsoor SS, Rani DD, Lathashree S, Nethra SS, Sudheesh K. Effect of intraoperative Dexmedetomidine infusion on sevoflurane requirement and blood glucose levels during entropy-guided general anesthesia. J Anaesthesiol Clin Pharmacol 2014;30:25-30.  [ PUBMED] [Full text] |
| 2. | Jüni P, Altman DG, Egger M. Systematic reviews in health care: Assessing the quality of controlled clinical trials. BMJ 2001;323:42-6. |
| 3. | Whitley E, Ball J. Statistics review 4: Sample size calculations. Crit Care 2002;6:335-41. |
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