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Year : 2011  |  Volume : 27  |  Issue : 4  |  Page : 500-505

Effect of intraoperative depth of anesthesia on postoperative pain and analgesic requirement: A randomized prospective observer blinded study

1 Department of Anaesthesiology, PGIMER, Chandigarh, India
2 Department of Anaesthesiology,Government Medical College and Hospital, Chandigarh, India
3 Department of Anaesthesiology, INSCOL Hospital, Chandigarh, India
4 Department of Anaesthesia and Intensive Care, Government Medical College and Hospital, Chandigarh, India

Correspondence Address:
Lakesh K Anand
Department of Anaesthesia and Intensive Care, Government Medical College and Hospital, Sector-32, Chandigarh - 160 030
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0970-9185.86595

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Background : Intraoperative depth of anesthesia may affect postoperative pain relief. This prospective, randomized, and observer-blinded study assessed the effect of intraoperative depth of anesthesia on the postoperative pain and analgesic requirements in patients undergoing laparoscopic cholecystectomy. Materials and Methods : A total of 80 patients were randomly divided into two groups of 40 each. A standard technique for anesthesia was followed in all patients. Depth of anesthesia was monitored by bispectral index (BIS) and adjusted with 0.5 to 1.5% isoflurane in group S by addition of propofol in group B, if required, to maintain a BIS value of 45 to 40. Postoperative analgesia was provided by tramadol 1 mg/kg every 6 hours and rescue analgesia by morphine boluses. Postoperative pain was assessed by Visual analogue scale score at 0, 8, 16, and 24 hours. Results : The demographic characteristics were comparable in both groups. The mean BIS value in Group S was 63.32 ± 11.43 and 45.06 ± 15.31 in Group B, well in the range of 40 to 60, reflecting adequate hypnotic effect for general anesthesia. The mean arterial pressure was low in group B throughout the surgery (P<0.05-0.001). The pain score were lower in group B at 0 and 8 hours postoperatively when compared with group S (P<0.05). The rescue analgesic requirement was less in group B, compared with group S (P<0.05). Conclusion : Maintaining BIS to a value of 45 to 40 throughout the surgery results in better postoperative pain relief and decreased requirement of rescue analgesic without any untoward effect.

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